Optimal parametric sensitivity control for a FED batch reactor

The paper presents a method to derive an optimal parametric sensitivity controller for optimal estimation of a set of parameters in an experiment. The method is demonstrated for a fed batch bio-reactor case study for optimal estimation of the saturation constant K
_s
and, albeit intuitively, the parameter combination μ
_max
X/Y where μ
_max
is the maximum growth rate [g/min], Y is the yield coefficient [g/g], and X is the (constant) biomass [g].