Electrochemical sensor for Serotonin based on a composite made of core-shell molecularly imprinted polymer nanoparticles and polyethilenedioxythiophene

The “grafting from” synthesis of core-shell molecularly imprinted polymer nanoparticles (Ser-MIP@SiO
₂
NPs) has been applied to the development of an electrochemical sensor for Serotonin. Ser-MIP@SiO
₂
NPs have been synthesized on preformed SiO
₂
nanobeads by surface imprinting via reversible additionfragmentation chaintransfer (RAFT) polymerization. After polymerization, the reductive aminolysis of dithioesther end group has been carried out. Then MIP-nanoparticles were subsequently characterized by ATR-FTIR, TGA, TEM and XPS. The entrapment of core-shell Ser-MIP@SiO
₂
NPs by the electropolymerization of PEDOT in an upside-down electrochemical cell has been investigated. Under selected conditions, results in sensing application for Serotonin are presented.