Challenges and advances of long-wavelength macromolecular crystallography at Diamond Light Source

The beamline I23 at Diamond Light Source will be the first dedicated beamline for long-wavelength phasing experiments from macromolecular crystals (MX). The challenges of in-vacuum long-wavelength macromolecular crystallography and the opportunities by extending the wavelength range towards the sulfur and phosphorous K-absorption edges will be discussed and an overview on the current status of the project will be given.