Quantitative analysis of brain SPECT with 99mTc-HMPAO in patients with mild cognitive changes

Mild cognitive disorders in patients is often not accompanied by focal changes in brain regions, which significantly complicates the objective assessment of pathology. Therefore, a new approach of quantitative analysis of brain single-photon emission computed tomography is developed. The analysis is based on calculating the average gradient of radioactivity distribution in a brain cross-section along a predetermined direction, as well as on Fourier spectra analysis, which are characterized by "1/f" (flicker noise) type behavior. Pilot clinical study of six patients shows promising prospects of the developed method.