Cerium oxide ISFETs based immune biosensor for the patulin control

The physical-chemical and functional characteristics of the immune biosensor based on the cerium oxide ISFET were presented. Horse radish peroxidase (HRP) served as label and its activity was measured by basic pH shift of ascorbic acid solution in the presence of H
2
O
2
. At the patulin analysis by the “competitive” way the detecting concentrations was up to 1.0 ng ml
⁻¹
and linearity in frame of 5–200 ngml
⁻¹
. In case of the “to saturate” way the sensitivity increased to 0.5 ngml
⁻¹
with the linearity in range of 1.0–250 ngml
⁻¹
.