Tissue perfusion in Fluid therapy

Fluid resuscitation affects blood flow and oxygen concentration. Administered fluid increases blood flow and oxygen delivery rate but also decreases blood oxygen concentration. This study aims at analyzing these two effects on oxygen supply to tissue to determine an optimal fluid regimen. For this purpose a hemodynamic model of the cardiovascular system and a model of oxygen transfer to tissue were developed and combined. Simulation results showed that indeed fluid administration increases oxygen delivery by the blood stream. However, oxygen transfer to tissue deteriorates during the course of the fluid therapy due to the high sensitivity of oxygen diffusion to oxygen partial pressure in the blood.