CMOS based high density micro array platform for electrochemical detection and enumeration of cells

A highly sensitive label-free complementary-metal-oxide-semiconductor (CMOS) based high density micro-array for electrochemical detection and enumeration of breast tumor cell (MCF-7) is presented. The electrochemical impedance spectroscopy (EIS) based detection platform exhibited detection at single cell resolution (22 μm) and enumeration with mapping accuracy of ~80%. Maximum tumor-cell impedance increase of 28% was recorded.