Expression of ADAM8 in Liver Cancer

ADAM8 (disintegrin and metalloprotease 8) belongs to a family of transmembrane proteins implicated in cell-cell interactions, proteolysis of membrane proteins, and various aspects of carcinogenesis. In this study, we want to evaluate whether ADAM8 is highly expressed in liver cancer. So western blot, RT-PCR and Immunohistochemistry were used to evaluate the expression of ADAM8 in liver cancer and normal liver. The results of western blot and RT-PCR show that ADAM8 is highly expressed in liver cancer. The result s of immunohistochemistry shows that ADAM8 is mainly expressed in the cytoplasm of liver cancer cells. Our results first prove that ADAM8 is expressed in the liver cancer, which may play important roles in the genesis and development of liver cancer.