Wiener model identification for muscle relaxation

This paper presents a Wiener model developed for muscle relaxation. The model consists of a linear transfer function and a nonlinear block based on a sigmoid network expansion. Data collected during surgery at Regional Institute of Gastroenterology and Hepatology “Prof. Dr. Octavian Fodor” are used to identify the parameters of this model. The input is atracurium, an intermediate-duration non-depolarizing neuromuscular-blocking agent used in anaesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. The output is the amplitude of the first twitch, a variable measured with the TOF-Watch SX device. The model identified proved to describe accurately the metabolism of atracurium.