Development of new cancer treatment using approved MRI contrast agent and induction heating device

MRI contrast agents, Feridex and Resovist have superparamagnetic substance as an active ingredients. Feridex does not show temperature rise under AC magnetic field. In contrast Resovist shows temperature rise under the same condition. We simulated the optimum frequency on Resovist using phantom and found it is 140 kHz. However treatable cancer volume was limited to 9cm
³
. We tried a fractionation of Resovist. One of the fractions was found to be effective by more than 6 times compared to the drug by itself. This result suggests that the hyperthermia in combination with the fraction and induction heating device is a promising treatment for cancer.