Real-time label-free detection of DNA synthesis by FBAR-based mass sensing

This paper reports a real-time detection of DNA polymerase reaction through mass sensing with film bulk acoustic resonator (FBAR) coated with self-assembled DNA sequences. This label-free, real-time detection of DNA synthesis can potentially lead to detection of single nucleotide addition for DNA sequencing application, which can be developed into a low-cost, third-generation DNA sequencing system capable of reading thousands of nucleotides in a single run.