Nonlinear system identification of the thalamocortical circuit in response to thalamic microstimulation

Sensory neural prostheses aim to restore lost sensory function by using electrical stimulation to deliver information about the external sensory environment. However, current electrical stimulation techniques suffer from a lack of stimulation specificity on a single electrode and complicated neural interactions from stimulation across multiple electrodes. Here we present the construction and validation of a single-input, single-output nonlinear model of the downstream cortical activity in response to thalamic microstimulation for use in improving current electrical stimulation techniques.