A physiologic-based circuit model of the postsynaptic region at the neuromuscular junction

A metal-oxide-semiconductor field-effect transistor (MOSFET) is used as the circuit analog to simulate a group of excitatory transmitter-gated ion channels. This analog is incorporated into a circuit model of the postsynaptic membrane at the neuromuscular junction. Simulation of the model yields an output representing the overall membrane potential of the postsynaptic region. Simulation is performed for the normal and pathologic (myasthenia gravis) states.