Morphometry in the ovariectomized rat model of osteoporosis after continuous and intermittent vibration

To research the change of bone structure in the osteoporotic rats after high frequency and low magnitude vibration with different intervals by histomorphometry. Forty-two wistar rats aged six months were divided into six groups, which were CG (control group), OCG (ovariectomized control group), CVG (continuous vibration group), IVGIO (intermittent vibration groups with interval of one week), IVGIT (intermittent vibration groups with interval of two weeks) and IVGIF (intermittent vibration groups with interval of four weeks). All the rats were executed by manual cervical dislocation after eight weeks. The bone trabecula structure, mineralization rate and other indicators of the rats' tibias were compared after resin embedded undecalcified section. It was shown that the high frequency and low magnitude stimuli would prevent osteoporosis and the best effect was obtained in the IVGIO.