Comprehensive Evaluation Model of DNA Codewords Based on Combined Weight Method

An evaluation problem of codewords for DNA computing was studied. The constraints on codewords design were discussed, five evaluation criteria: distance constraint, GC-content, continuous bases, melting temperature and free energy were presented. According to the correlation of the criteria, the combined weight method, which based on statistics principle was proposed, and then a comprehensive evaluation model for evaluating DNA codewords, was also developed. The simulation result showed the feasibility and validity of the comprehensive evaluation model.