Modeling the cell cycle of fission yeast by means of piecewise linear systems

Biological process modeling requires the use of a non-LTI description. On the other hand, experimental data suggest that the behavior of many biological systems can be described with good approximation by means of piecewise Linear Time-Invariant (LTI) models. On the basis of these considerations, the present work focuses on the problem of analyzing a set of experimental data and identifying the points where discontinuous phenomena occur. A validation of the technique is provided exploiting the well established cell cycle model of fission yeast by Novak and Tyson.