An in-vivo comparison study between standard and PET-based approach to assess the therapeutic dose in neutron capture therapies

Previous studies[1,2] dedicated to the evaluation of the best approach for a treatment plan more consistent with the clinical findings started a vexata quaestio, which is still an open issue as demonstrated by the fact that BNCT treatment plans are only partially based on the pre-evaluation of the macroscopic boron distribution. For example, the evaluation of the T/N ratio through pre-irradiation PET scanning is undoubtedly a major improvement[3].