A method for assessing significant changes in serial ECG comparison

Our method for the evaluation of serial ECG records is based on the assumption that major intra-individual quantitative changes of ECG measurements are associated with the development of -or recovery from - pathophysiologic changes. The criteria for significant changes were derived from standardized twelve lead resting ECGs of 860 men and women, who were participants of a population-based survey and a two year follow-up study of the KORA Project Augsburg. The ECG changes derived from repeated records by this approach were significantly associated with the individualspsila history of cardiac disease.