Towards a Brain-Machine-Brain Interface (BMBI) for Anatomical Rewiring of Cortical Circuitry

One major hurdle in designing prosthetic devices to restore function after brain injury is the inability for the mature brain to reestablish normal neuronal connection patterns. Combining neurobiological tools with state-of-the-art implantable device technology could potentially offer a novel approach for orchestrating new long-range connections in the cerebral cortex after injury. In this paper, we report on our progress towards developing a fully implantable brain-machine- brain interface (BMBI) to reshape cortical connections after brain injury by coupling activity between distant cortical locations using CMOS-integrated recording, neural signal processing, and microstimulation circuitry.