Platelet damage accumulation: In vitro and mathematical models

A phenomenological model for platelet cumulative damage was developed to express the platelet activation state (PAS) in response to a specific shear stress loading waveform. genetic algorithms (GAs) were used for model identification. The model was fine-tuned using parameters obtained in vitro by application of a shear stress loading waveform to a Hemodynamic Shearing Device (HSD). The PAS was measured temporally using a modified prothrombinase method. The proposed analytical model and PAS prediction agree well with and follow the same trend as the experimental results.