Influence of SOD Mimics on Activities of Cultured Hepatoma Cell Line

Based on the free radical theory, considerable effort has been made in biochemistry to develop SOD mimics as therapeutic agents to eliminate excessive free radicals. Among widely used mimics, the SOD mimics (also named as the model of SOD, MSOD) have been indicated promising results with the possible future applications as a new antitumor medicine in clinic. The present study showed that this SOD mimic can inhibit the proliferation of human hepatoma SSMC-7721 cells and significantly affect cell cycles. These preliminary findings may pave the way for its wider application.