Predictive Models for Long Term Survival after Premature Rupture of Membranes

Premature rupture of the membranes complicates 30 to 40% of the preterm deliveries. The purpose of this study is to assess the outcome of preterm prelabor rupture of the membranes (PPROM) before 26 weeks of gestation and to develop a predictive model for survival. We apply four statistical methods in order to construct a predictive model: Cox's Proportional Hazards model, Logistic Regression, Least Squares - Support Vector Machines and Generalized Estimating Equations. The obtained predictive models are tested on a prospective set and have a very good performance of >95% for the area under the ROC-curve.