Modelling hydrophobicity to identify secondary structure signals in globular proteins

In globular proteins the hydrophobic effect is a well-known phenomenon that is more and more investigated in relation with protein folding. The Discrete Fourier Transform of the hydrophobic profile of the primary structure, resulting in the so-called amphipatic plots, allow to identify some regular structures. We present a modelling method, which aims to improve both the user-friendliness and the quality of the representation of the amphipatic plots.