Dielectrophoretic manipulation of avidin and DNA

This paper demonstrates the application of dielectrophoresis (DEP) to the manipulation of biological macromolecules such as avidin and plasmid DNA. We report, for the first time, observations of negative dielectrophoresis of these macromolecules which can be used to perform stable trapping. The basic electrokinetic theory and experimental arrangements for realising DEP in microelectrode structures are described. The paper discusses our observations on the DEP manipulation of these macromolecules.