New Target Controlled Infusion Using a Hybrid Physiologically Based Pharmacokinetic Model

New target controlled infusion (TCI) for propofol using a hybrid physiologically based pharmacokinetic (PBPK) model was proposed in this paper. The hybrid model was composed of a three-compartment mamillary systemic model and a two-compartment brain model. A closed-loop control algorithm with brain concentration as the control variable was used to calculate the infusion. Finally, the dose regimen was applied in clinical practice and the recorded auditory evoked potentials showed good depth of anaesthesia. The TCI was feasible and had potential applications.