Heat Element of Magnetic Hyperthermia in Mouse Melanoma Model

The soft-heating method is one kind of heating technique of hyperthermia. The feature of this method is to use thermosensitive magnetic material as the heat element. This means the heat element can control the temperature automatically, referring the Curie-point of the thermosensitive ferrite. The heat element consists of a thermosensitive ferrite and metal ring. The purpose of the metal ring wrapped to ferrite is to increase heat quantity compared with that of ferrite alone. In this study, the effect of the heat element in mouse tumor model (B-16 melanoma) is examined. As a result, the tumors of mice were locally heated to the point at which tumor is necrotized in the condition of 200 kHz–6 mT.