Development and initial results of a dual-modalitySPECT/optical small animal imager
Peter, J.
Ruehle, H.
Stamm, V.
Schulz, R.B.
Smith, M.F.
Welch, B.
Popov, V.
Kross, B.
Wojcik, R.
Weisenberger, A.
Majewski, S.
Semmler, W.
Dept. of Med. Phys. in Radiol., German Cancer Res. Center, Heidelberg, Germany
This paper appears in: Nuclear Science Symposium Conference Record, 2005 IEEE Publication Date: 23-29 Oct. 2005
Volume: 4
On page(s):
4 pp.
ISSN: 1082-3654
ISBN: 0-7803-9221-3
Digital Object Identifier: 10.1109/NSSMIC.2005.1596718
Current Version Published: 2006-02-27
Abstract
We have developed a dual-modality single photon (SPECT)/optical (OT) small animal tomographic device to image simultaneously and from identical projection angles in vivo distributions of bioluminescent/(near-infrared) fluorescent and radiolabeled markers. For the SPECT sub-system a compact gamma detector has been developed. A custom-made pinhole (PH) collimator suitable for attachment of reflective surfaces for concurrent optical imaging has been built. The collimator's reflective surfaces filter out optical photons from the multi-energetic photon flux. These photons are directed into a system of mirrors to compose an optical projection that is aligned with the angular field of view of the PH SPECT camera. For the optical detector sub-system a high resolution cooled CCD camera is used. In addition to initial small animal imaging studies several experimental phantom studies were performed with capillary tubes filled with various isotopes and optical markers to evaluate energy/wavelength/tissue dependent spatial resolution capabilities of the sub-systems.
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