In vivo colposcopic imaging of neoplastic tissues using optical coherence tomography

Summary form only given. In order to investigate the diagnostic utility of OCT for identifying markers of dysplastic change, an integrated OCT colposcope has been developed and used for clinical imaging. The integrated colposcope has a 300 mm long working distance and permits a simultaneous en face view of the cervix with real time OCT imaging. This design enables OCT images to be registered with the standard colposcopic view of cervical pathology. The OCT colposcope enables acquisition of cross-sectional tomographic images of cervical tissue. Images could be obtained with 15 /spl mu/m resolution at a rate of 4-8 frames per second for 500 and 250 transverse pixel images.