mm-wave dielectrometry methods for prediction, prevention, diagnostics and individual treatment at acute cardiac infarction and cardiomyopathy

The aim of this work is the elaboration of methodology for prediction, prevention, diagnostics and individual treatment of cardiovascular pathology relevant to the molecular-cellular mechanism disturbances of membrane receptors functioning in the adenylate cyclase system (ACS) and cytoskeleton complex. The authors use dielectrometry data in the region of free water dispersion in acute cardiac infarction (ACI) and cardiomyopathy. Dielectrometry at extremely high frequencies (EHF-dielectrometry) along with biochemical technology enables the authors to conduct cellular level screening when acting upon various control complexes of a cell with biologically active agents in real time, under conditions which avoid object destruction. For the analysis the authors use the modification of cell water environment conditions, resulting from component conformational transformations on the specific binding of biologically active substances. The integration of modern biochemical and radiophysical methods has allowed the development of a new methodological approach to the analysis of cell regulating systems using nondestructive monitoring conditions and operating in real time.