Estimation-based model predictive control of blood glucose in type I diabetics: a simulation study

A constrained state space model predictive controller, designed based on a 3-state model of the human glucose-insulin interaction, was implemented on a 19-state simulation model of a Type I Diabetic patient. The controller maintained the blood sugar level of the patient plant between the values of 60 and 130 mg/dl, when subjected to a meal disturbance of 50 g, significantly lowering the risk of hypoglycemia/hyperglycemia.