A high-temporal resolution algorithm to quantify synchronization during atrial fibrillation

Introduces a new measure of synchronization between electrical activity of relatively close atrial sites during Atrial Fibrillation (AF). It assesses the probability of finding synchronous activations in intra-atrial bipolar electrograms. Data were obtained using multipolar basket catheter in the right atrium, in informed patients during AF. The Index of Synchronization (IS) is based on the assumption that two activations closely spaced in time are likely to belong to the same depolarization wavefront (i.e. synchronized). Relevant features of the proposed index are the high temporal resolution and the robustness to activation time estimation error, to missing or false detections and to the ever changing pattern of propagation, typical of the AF.