A distributed scheme for efficient pair-wise comparison of complete genomes

The comparisons of newly sequenced genomes against a genome with known functionality of genes provide important clues to the structure and function of genes and identification of metabolic pathways in newly sequenced organisms. New and more complex organisms are being added to biological databases at an increasing rate. Time-efficient, automated computational methods are needed to analyze the increasing amount of data in realistic time. This paper describes a distributed technique and a CORBA-based implementation to compare and align gene sequences in large complete genomes, using multiple heterogeneous distributed processors on a distributed network. The performance evaluation suggests that the distributed technique can significantly reduce the computational time.