Significance of the −2propsa index and the prostate health index in patients with prostate cancer: A literature review and data of the Russian prospective study

The current literature review provides an analysis of fundamental studies on the -2proPSA index and prostate health index PHI and determination of their role in patients with prostate cancer. The authors revealed the basic aspects of the studied markers such as the improvement of prostate cancer detection, increase of specificity and reduction of unnecessary biopsies, identification of aggressive forms of prostate cancer, as well as the usage of the indicators to measure the progression of the disease. The results of numerous studies, including preliminary results of Russian studies on new indicators, are promising and for today allow us to recommend the use of the test to determine the values of -2proPSA Index and prostate health PHI in daily urological practice.