Modeling and identification of cardiovascular hemodynamics in a closed-loop model with ventricular interaction

A closed-loop model of the cardiopulmonary circulation has been developed for the study of right-left heart interaction under physiologically normal and altered conditions. Model parameters are identified via comparison with canine hemodynamic data using a Levenberg-Marquardt algorithm. The core model provides insight into the affects of ventricular interaction and the pericardium on hemodynamics. Alterations of model parameters can be used to predict the impact of disease and/or clinical interventions on steady-state hemodynamic performance.