Design and Investigation on Bioinverter and Bioring-Oscillator for Dielectrically Modulated Biosensing Applications

In this work, an inverter-based biomolecule detection strategy has been introduced for dielectrically modulated biosensing applications that show a clear output logic-state transition after conjugation. Subsequently, a bioring-oscillator has been realized based on such bioinverters, where biomolecules can be detected from the oscillation frequency amplification with conjugation. To optimize the detection efficiency, a dielectrically modulated fringing field effect transistor based transducer has been incorporated as the pull-up/pull-down elements of such bioinverter. The underlying physics of such structure has been investigated and subsequent electrical response has been estimated for various biomolecule sample specifications. This work explores different bioinverter configurations, and subsequently the suitable choice of bioinverter has been indicated for charged and charge-neutral biomolecule detection. Similar studies have been performed for bioring oscillator, and the roles of supply voltage scaling and oscillator stage enhancement have been investigated in this context.