ResCSRF: Algorithm to Automatically Extract Cheyne–Stokes Respiration Features From Respiratory Signals

Objective: Cheyne-Stokes respiration (CSR) related features are significantly associated with cardiac dysfunction. Scoring of these features is labor intensive and time-consuming. To automate the scoring process, an algorithm (ResCSRF) has been developed to extract these features from nocturnal measurement of respiratory signals. Methods: ResCSRF takes four signals (nasal flow, thorax, abdomen, and finger oxygen saturation) as input. It first detects CSR cycles and then calculates the respiratory features (cycle length, lung-to-periphery circulation time, and time to peak flow). It outputs nightly statistics (mean, median, standard deviation, and percentiles) of these features. It was developed and blindly tested on a group of 49 chronic heart failure patients undergoing overnight in-home unattended respiratory polygraphy recordings. Results: The performance of ResCSRF was evaluated against manual expert scoring (ES) (consensus between two independent sleep scorers). In terms of percentage of CSR per recording, the mean difference [reproducibility coefficient (RPC)] between ResCSRF and ES was -0.5(6.4) and 0.5(8.1) for development and test set, respectively. The nightly statistics of CSR-related features output by ResCSRF showed high correlation with ES on the blind test set with the mean difference of less than 3 s and RPC of less than 7 s. Conclusions: These results indicate that ResCSRF is capable of automating the scoring of CSR-related features and could potentially be implemented into a remote monitoring system to regularly monitor patients' cardiac function.