A Gene–Protein–miRNA Electronic Oscillator

This brief presents an electronic oscillator circuit model mimicking a unique relationship among six genes. Three out of the six genes are employed to synthesize proteins, while the remaining three are their complementary micro-ribonucleic acid (miRNA) genes degrading the messenger-RNA transcripts at the translational level of gene expression. The circuit runs without any external stimulus because the transcription of each gene is controlled by another gene in forming the oscillatory network. A feasibility procedure is also presented, which can be used to fabricate the proposed gene-protein-miRNA electronic oscillator in the biological domain. This research is valuable in designing complex synthetic gene regulatory networks and analyzing their biological behavior.