Challenges in modeling nerve-electrode interactions of neuronal implants

This paper accompanies a tutorial on challenges in modeling of nerve-electrode interactions in the context of neurochips and cochlear implants. We highlight on the biological processes that needs consideration in modeling the extracellular phenomena and their interaction with the electrodes. We first emphasize on the importance of mathematical models in abstracting the biological phenomena of nerves. Secondly, we show how a multi-physical approach is needed in these mathematical models. Finally, we take up an example of cochlear implant to demonstrate the importance of several features that needs consideration in modeling.