Discrete time state feedback with setpoint control, actual state observer and load estimation for a tumor growth model

With the current scientific knowledge, there is no medical device which can handle continuous infusion cancer therapy. Hence, only a quasi continuous infusion therapy can be achieved using discrete drug administration (which can be sufficiently frequent). Therefore, a discrete time control has to be designed for a tumor growth model for real-life application. We designed state feedback control, augmented with setpoint control to follow nonzero reference signal, and also augmented with actual state observer due to the fact that we are unable to measure all states of the system. In addition, the control system contains load estimation as well to investigate the effect of disturbance on the input of the model.