Ingestible, controllable, and degradable origami robot for patching stomach wounds

Developing miniature robots that can carry out versatile clinical procedures inside the body under the remote instructions of medical professionals has been a long time challenge. In this paper, we present origami-based robots that can be ingested into the stomach, locomote to a desired location, patch a wound, remove a foreign body, deliver drugs, and biodegrade. We designed and fabricated composite material sheets for a biocompatible and biodegradable robot that can be encapsulated in ice for delivery through the esophagus, embed a drug layer that is passively released to a wounded area, and be remotely controlled to carry out underwater maneuvers specific to the tasks using magnetic fields. The performances of the robots are demonstrated in a simulated physical environment consisting of an esophagus and stomach with properties similar to the biological organs.