Closed-loop system for total intravenous anesthesia by simultaneously administering two anesthetic drugs

Total Intravenous Anesthesia (TIVA) for general anesthesia using Propofol (a hypnotic) and Fentanyl (a narcotic) is a popular technique. When designing computer control of TIVA, the main difficulty is how to determine the infusion rate of two interacting drugs. In this paper, the authors mainly address the simulation results on the interaction model of two drugs, how to use the model to simultaneously control infusion rates and how to incorporate it into an Automatic Anesthesia Management System (AAMS) for TIVA. The paper provides a novel idea regarding how to design closed-loop system for simultaneously administrating two drugs in TIVA.