Chemical IC chip for dynamical control of protein synthesis

The several types of biochemical IC chips with photodetective micro reactors have been developed. The real-time monitoring and control of cell free synthesis of protein was demonstrated successfully. The photo protein of the firefly, the so called Luciferase, was synthesized. The biochemical luminescence was monitored by a built-in photodiode in the micro reactor to transfer reaction status into a voltage signal. Feedback control synthetic reaction was verified experimentally. The results achieved here should be key technology for future DNA and RNA synthesis without a biological cell.