Model study of vectorcardiographic manifestation of heterogeneous left ventricular hypertrophy

A computer model of propagated activation with analytically defined geometry of ventricles was used to study the effect of localised asymmetric hypertrophy of the left ventricle on the resultant cardiac vectors. The thickness of the wall in the interventricular septum, in the anterior, posterior and lateral free wall, respectively, was increased either centrifugally or centripetally to 160% of its reference value. Significant increase of the magnitude of resultant cardiac vectors was found when the lateral and posterior parts of left ventricle were thickened. In the case of interventricular septum, simulated hypertrophy led to a decrease of the magnitude of these vectors.