Simulation of cervical cancer response to radiotherapy

The goal of this article is to present basic scientific principles and core algorithms of the simulation module of the CERvical cancer ONCOsimulator (CERONCO) developed within the context of the DrTherapat project (FP7-ICT-600852). CERONCO simulates the response of cervical tumours to radiotherapy treatment (external beam radiotherapy followed by brachytherapy) with concomitant weekly cisplatin, in the patient-individualized context. Results from a preliminary clinical adaptation study based on the MR imaging data of a clinical case are presented as well.