Biomechanical analysis of aortic valve

The purpose of this study was to investigate the physical effects of aortic valve stenosis on the human heart, as well as to link the progression of aortic valve stenosis to the homeostatic mechanisms and sensitivity of the heart. Mean systolic pressure gradient (in mmHg) values are used as input into the equation produced aortic valve areas. Higher pressure gradient values produced smaller aortic valve areas, and thus indicated that aortic valve stenosis area was inversely proportional to mean systolic pressure gradient value across the valve. With the conclusion of our findings, it was determined that aortic valve stenosis was responsible for initial aortic valve area decrease, but progression of aortic valve stenosis was compelled by the maladaptive and contradictory feedback mechanisms of the heart responsible for maintaining blood flow stability.