Physiological feature analysis in Heart Rate Turbulence using LASSO model

Heart Rate Turbulence (HRT) is a relevant cardiac risk stratification criterion. It is usually assess by means of turbulence slope (TS) and turbulence onset (TO) parameters. HRT is known to be affected by several physiological factors, mainly heart rate (HR) and coupling interval (CI). The physiological hypothesis accepted is the baroreflex source of the HRT. However, several studies showed different results about the relationship between CI and HRT parameters. Our aim was to propose a complete LASSO model using CI and sinus cardiac length (SCL), their powers and an interaction term as explanatory variables to account for the physiological dynamic of the TS parameter.