A comparison of two models of human ventricular tissue: Simulated ischaemia and re-entry

Several models of the human ventricular action potential have been developed. The aim of this study was to compare the dynamical behaviour and impact of simulated ischaemia in two cell models: the O'Hara-Rudy dynamic (ORd) model, and the Ten Tusscher-Panfilov 2006 (TP06) model. The endocardial variant of each cellular model was embedded in a 2D monodomain tissue model, and solved with an explicit finite differences approach with a fixed space step of 0.2 mm and time step of 0.005 ms. Action potential duration (APD) and conduction velocity (CV) restitution were measured using an S1S2 protocol with S1=1000ms. Despite different formulations for both transmembrane currents and calcium handling in these models, the dynamical behaviour and their response to simulated ischaemia in these models was similar.