Towards patient personalization of an Acute Lymphoblastic Leukemia Model during the oral administration of prednisone in children: Initiating the ALL Oncosimulator

In the present study, methods aiming at supporting the personalization of an Acute Lymphoblastic Leukemia (ALL) Model (ALL Oncosimulator), already in development by the In Silico Oncology Group, National Technical University of Athens, are provided. Specifically, a population pharmacokinetic model for orally administered prednisone in children with ALL is developed, and the ability of classification algorithms to predict the prednisone response using gene expression data is studied.