Computer-aided tissue engineering for bone regeneration

Computer-aided tissue engineering comprises a set of methodologies for the fabrication of prosthetic implants by means of rapid prototyping technologies. The paper presents a technique for the preparation of bioactive implants intended to be used in combination with mesenchymal stem cells for the regeneration of bone tissue. The methodology uses additive manufacturing of scaffolds according to a topological optimization algorithm and combines it with chemical functionalization protocols to increase material bioactivity.