Synthesis of oligomer with N-(O, O-diisopropyl) — Phosphoryl arginine and its effect on 5-hydroxytryptamine receptor

Oligorrer (OMPA) with N-(O, O-diisopropyl) phosphoryl arginine (DIPP-Arg) has been synthesized and its structure has been identified by IR,
¹
H NMR,
^3l
P NIVR, and elemental analysis. The functional conversion ratio of this reaction was found to be about 30%. The effect of OMPA on the 5-hydroxytryptamine (5-HT) receptor was studied by a functional test of constriction in rat blood vessels. The results showed that OMPA inhibited 5-HT receptor-induced blood vessels constrictions with pD
2
values of 5.65 ± 0.21 (OMPA) and 7.45 ± 0. 30 (DIPP-Arg) and exhibited significant pharmacological action of antagonism effect on the 5-HT receptor.